Sonic hedgehog (SHH) regulates c-myc expression in the developing brain: Direct or indirect link?
نویسندگان
چکیده
منابع مشابه
Role of Sonic Hedgehog (Shh) in Alcohol-Induced Craniofacial Abnormalities
Prenatal exposure to alcohol (ethanol) results in a continuum of physical and neurological developmental abnormalities that vary depending on the timing, duration, and degree of alcohol exposure. Heavy exposure during development may lead to the condition Fetal Alcohol Syndrome [6] (FAS), characterized by growth deficits, neurological deficiencies and minor facial abnormalities. Alcohol is a kn...
متن کاملRole of Sonic Hedgehog (Shh) in Alcohol-Induced Craniofacial Abnormalities
Prenatal exposure to alcohol (ethanol) results in a continuum of physical and neurological developmental abnormalities that vary depending on the timing, duration, and degree of alcohol exposure. Heavy exposure during development may lead to the condition Fetal Alcohol Syndrome [6] (FAS), characterized by growth deficits, neurological deficiencies and minor facial abnormalities. Alcohol is a kn...
متن کاملC-myc and N-myc in the developing brain
(KO) of myc genes have provided substantial insight into not only their normal functions during development, but also shed light on their tumorigenic functions when they are misregulated. c-myc and N-myc genes both are essential in neural stem and precursor cells (NSC) for normal mouse brain growth[1, 2]. The fact that mutation of N-myc also causes microcephaly in humans in Feingold Syndrome[3]...
متن کاملExpression Profile of Sonic Hedgehog Pathway Members in the Developing Human Fetal Brain
The Sonic Hedgehog (SHH) pathway plays a central role in the developing mammalian CNS. In our study, we aimed to investigate the spatiotemporal SHH pathway expression pattern in human fetal brains. We analyzed 22 normal fetal brains for Shh, Patched, Smoothened, and Gli1-3 expression by immunohistochemistry. In the telencephalon, strongest expression of Shh, Smoothened, and Gli2 was found in th...
متن کاملRole of Sonic Hedgehog (Shh) in Alcohol-Induced Craniofacial Abnormalities
Prenatal exposure to alcohol (ethanol) results in a continuum of physical and neurological developmental abnormalities that vary depending on the timing, duration, and degree of alcohol exposure. Heavy exposure during development may lead to the condition Fetal Alcohol Syndrome [6] (FAS), characterized by growth deficits, neurological deficiencies and minor facial abnormalities. Alcohol is a kn...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2009
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2009.05.192